| Elie D.
Al-Chaer Curriculum Vita |
 
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NAME: Elie Diab Al-Chaer PRESENT ACADEMIC POSITION AND ADDRESS
Professor (Tenured)
Director
Electronic Address:
Homepage: http://www.alchaer.comLabpage: http://www.uams.edu/acelabE- mail: ealchaer@uams.eduPhones: Off. (501) 526-7828/9Lab (501) 526-7830/1/2Admin. Asst. (501) 526-7863/4
Res. Assoc. (501) 526-7865/6/7/8
BIOGRAPHICAL
LANGUAGES: English, French and Arabic (All 3 fluently spoken, read and written)
EDUCATION After finishing High School at the “Collège des Frères, Mont La Salle” (a Private French Catholic Missionary School) Aïn Saadé, Lebanon, 1985-1988: Undergraduate student, Department of Mathematics, Faculty of Arts and Sciences, American University of Beirut (AUB), New York Universities Board, Beirut, Lebanon
1989-1991: Graduate student, Department
of Physiology, Faculty of Medicine, American University of
1993-1996: Ph.D. student, Graduate School of Biomedical
Sciences (GSBS), 1997-2002: Law Student, South Texas College of Law (STCL), Houston, Texas, USA
DEGREES
B.S. (May 1988) Mathematics, Faculty
of Arts and Sciences, American University of Beirut,
M.S. (Aug.1991) Physiology, Faculty
of Medicine, American University of Beirut, New York
Universities
Ph.D. (Dec. 1996) Neuroscience,
Graduate School of Biomedical Sciences, University of Texas
Medical J. D. (May 2002) Doctor of Jurisprudence, South Texas College of Law, Houston, Texas, USA
MASTER OF SCIENCE (MS)
American University of Beirut
Title:
Dorsal column input into the nucleus locus coeruleus in cats. Dept. of Physiology, AUB Professor Nayef E. Saadé D.Sc. Chairman, Dept. of Human Morphology, AUB Committee: Samir Atweh M.D. Chairman, Dept. of Internal Medicine, AUB Camille Nassar Ph.D. Chairman, Dept. of Physiology, AUB
DOCTOR OF PHILOSOPHY (Ph.D.)
University of Texas Medical Branch at
Galveston
DISSERTATION PROPOSAL
DISSERTATION
Title:
The dorsal column: a dynamic interactive polymodal channel for
visceral and somatic Defense date: October 24, 1996 Supervisor: William D. Willis Jr., M.D., Ph.D. Cecil H. and Ida M. Green Professor Director, Marine Biomedical Institute, UTMB Committee: Jin Mo Chung, Ph.D. Professor, Dept. of Anatomy and Neurosciences, UTMB Robert D. Foreman, Ph. D.
Professor and Chairman, Dept. of Physiology and Biophysics,
University of Haring Nauta, M.D., Ph.D. Director, Division of Neurosurgery, UTMB Luis Reuss, M.D. Professor and Chairman, Dept. of Physiology and Biophysics, UTMB Karin N. Westlund, Ph.D. Professor, Dept. of Anatomy and Neurosciences, UTMB
PROFESSIONAL WORK HISTORY
TEACHING EXPERIENCE 2007 (Apr.) - Lecturer, 2 lectures (Neuroscience of Pain: Mechanisms and Pathways & Syndromes and Modulation: 1.5 hour ea.), Cellular and Developmental Neuroscience, Graduate School, University of Arkansas for Medical Sciences, Little Rock, AR. 2006 (Nov.) - Lecturer, Graduate Neuroscience Course, Graduate School, University of Arkansas for Medical Sciences, Little Rock, AR. 1 lecture: “Pain” (Fall Term, 1 contact hour) 2006 (Apr.) - Lecturer, 2 lectures (Release of Neurotransmitters and Neurotransmitter Receptors: 1.5 hour ea.), Cellular and Developmental Neuroscience, Graduate School, University of Arkansas for Medical Sciences, Little Rock, AR. 2005 (Apr.) - Lecturer, lecture on Pain, Neuroscience Course, MED I, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR. 2003 (May) Invited chair and speaker, Professional Symposium on “Central sensitization in visceral pain” – Digestive Disease Week 2003, Title of talk: “Animal models of central sensitization in visceral pain” Orlando, Fl, USA. 2003 (Spr.) Laboratory teacher, Human Neuroscience and Behavior Course, MED I, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. (50 contact hours) 2003 (Mar.) Speaker, Professional Development Course “Stress and the Gut”, British Society of Gastroenterology, Birmingham, UK. 2000 - 04 Course Director and Lecturer, Core Pain Conference (NEUX 6000-013), Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston, Texas, USA. 2000 - 02 Lecturer, lecture on “Visceral Pain and Irritable Bowel Syndrome” GI and Nutrition Course, MED II, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. 2000 (Nov.) Moderator and Speaker, Professional Development Course on the Management and Pathophysiology of Visceral Pain, American Pain Society, 19th Annual Meeting, Atlanta, GA, USA. 1999 - 2002 Facilitator, Human Neuroscience and Behavior Course, MED I, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. (50 contact hours per year) 1999 Laboratory instructor, Human Neuroscience and Behavior Course, MED I, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. (50 contact hours) 1995 Teaching Assistant of Neuroscience, First Year Medical School (MED I), Faculty of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. 1992 Instructor of “Biomechanics of Human Motion” at the Department of Orthopedics and Orthotics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
CURRENT RESEARCH / FUNDING
A. Research Profile and Interests: As a scientist, I come from the land of the high-minded yet often curiously parochial primate. I believe that science starts with human interactions: if we want theory and experimental neuroscience to strengthen each other, we must hope for people with different cultures, expertise, perspectives and footwear to leave their prejudices at the door and learn to better appreciate each other’s strengths. This is not easy to achieve when human nature makes us shun the unfamiliar and puts us face to face with some of the most bewildering questions in life’s highly sophisticated machine “the living organism”. Yet, the makeup of my lab team embodies the philosophy of outstanding diversity. We are a group of excellent scientists (2 postdoctoral fellows, 2 research assistants, 1 technician and myself) from different areas of the globe guided by the Truth and limited by our imagination. As their leader, I promote high standards of research so as to advance knowledge and scholarship and encourage improvement and innovation in an environment of excellence, open mindedness, and outreach. As a neuroscientist, I would consider most of what we do in the lab as descriptive; we try to tie one observation to another through some causal link. Causal links are usually pretty short and linear, even when experiments to establish them are horrendously complex. However, to understand the brain and its collective behavior, we will have to understand a system of interacting elements of befuddling size and combinatorial complexity. Comprehension of the nervous system is very difficult to deduce from knowledge of its basic components; this is when we begin to theorize and bring about a new dimension of explanatory power. My research explores the neural changes associated with or residual to neonatal injury. Over the past three years, my laboratory has developed an animal model of chronic hypersensitivity and functional disorders. In this model, we expose newborn rat pups to inflammatory or nociceptive treatments and follow their development. The model is used to study the development and plasticity of sensory-motor circuitry, particularly the developmental and sometimes permanent structural, functional and behavioral alterations in the adult organism. In my work, I often collaborate with many of the outstanding research teams in the USA and beyond. My research has important clinical implication, in that many functional behavioral disorders find their roots in neonatal sensory overload or deprivation. The adult animals we study provide a useful tool to model some of the most puzzling human functional disorders (e.g. irritable bowel syndrome) in rats and study the underlying pathology. The long-range aim of my research is to identify specific functional circuits in the nervous system and the neurotransmitters they employ in an attempt to explain some of the complex syndromes of adult functional behaviors in terms of neonatal developmental anomalies. My research has appeared in more than 100 publications (abstracts, book chapters and papers), and has made news on more than one occasion. It is funded by generous grants from the National Institutes of Health in the USA (NINDS and NIDDK) and has peaked the interest of a number of pharmaceutical companies (two of which are currently funding us in collaborative research programs). For a deeper insight into my current research see Research Perspective (provided on demand) or visit my lab website (www.uams.edu/acelab).
B. Trainees and Visiting Scientists
2008 Jennifer Leigh Atchison (BS), MD/PhD student, UAMS 2008 Krishnapraveen Yadlapalli (MS), Research Technician, UAMS 2006 (Fall) Omar Rahal (MS), Graduate Student, UAMS 2005- Parul Soni, (BS), Research Technician, UAMS 2004- Chunping Gu, (MD), Research Associate, UAMS 2003- Jing Wang, MD PhD, Visiting Scholar, UTMB, UAMS 2002-2006 Xin Peng (B.S.), Research Assistant, UTMB, UAMS 2003-2004 Jiangang Xie (MD, PhD), Research Investigator, UTMB 2002-2004 Rodger Song (B.S.), Research Assistant, UTMB 2002-2003 Christine Hinze (M.S.), Research Scientist, UTMB 2001-2003 Chun Lin (MD, PhD), Visiting Scientist, UTMB 2001 Kimberly Hicks (B.S.), Trainee, UTMB 2001-2002 Huaxian Ma (MD), Research Scientist, UTMB 2000-2001 Kennichi Arai (MD, PhD), Postdoctoral Fellow, UTMB 1999-2000 Kawasaki, Motohiro (M.D., Ph.D.), Postdoctoral Fellow, UTMB 1999(Summer) Broussard, Robert (MED II), Medical Student Summer Training, UTMB
C. Grant Support
1) Active Research Grants: Grant 1: “Sex Hormones and Visceral Hypersensitivity” Elie Al-Chaer, Ph.D.: Principal Investigator (50%) 04/01/08-03/31/13 $1,800,000.00 Agency: National Institute of Digestive Diseases and Kidney Type: RO1 DK077733 In this study, we propose to identify the hormonal basis of the observed sexual dimorphism in visceral pain as well as the underlying physiological mechanisms. The central hypothesis is that sex hormones play a crucial role in the sex-specific differences in visceral pain possibly via their action on pain pathways in the central nervous system. Sex hormones modulate visceral sensitivity and central neural sensitization via direct action on estrogen receptors located on PSDC neurons or regulation of glutamate receptors located on these neurons. Defining the physiological and cellular mechanisms that contribute to sexual differentiation in persistent visceral hypersensitivity is of central importance to advancing our understanding of visceral hypersensitivity and to fostering a new approach to gastrointestinal disorders that leads to the development of new, gender-sensitive, therapeutic tools for the management of chronic visceral pain.
2) Pending Research Grants:
“Role of Microglia in Chronic Visceral Pain” Elie Al-Chaer, Ph.D.: Principal Investigator (20%) Pending $250,000.00 Agency: National Institute of Digestive Diseases and Kidney Type: R21; Score: 139 (6/2/08)
Grant 2: “Spinal Microglial Mechanisms of Visceral Hypersensitivity” Carl Saab, Ph.D.: Principal Investigator Elie Al-Chaer, Ph.D.: co-Investigator (10%) Pending $250,000.00 Agency: National Institute of Digestive Diseases and Kidney Type: R21
3) Completed Research Grants:
b) National Institute of Health:
Grant 1: “Mechanisms of Chronic Visceral Hyperalgesia” Elie Al-Chaer, Ph.D.: Principal Investigator 04/01/01-03/31/07 $1,450,000.00 Agency: National Institute of Neurological Disorders and Stroke Type: 1 RO1 NS/DK 40434
The long-term objective is to show that persistent visceral hyperalgesia, residual to neonatal colon irritation, is associated with central neural sensitization maintained by an interactive exchange of information between the spinal gray matter and the thalamus. This sensitization occurs as a result of colon irritation during a window of time in postnatal development and involves: a) amplification of sensory signals in visceroceptive areas of the spinal cord and the thalamus, b) alterations in signal processing involving glutamatergic and peptidergic processes, and c) an intact dorsal column - thalamus communication.
Grant 2: “Visceral Pain” (Identifies a new component of the postsynaptic dorsal column pathway and investigates its role in visceral nociception). Project 1 of a Program Project Grant (6 individual projects): Program Director: William D. Willis, M.D., Ph.D. Elie Al-Chaer, PhD.: Collaborator 08/01/01-07/31/04 Agency: National Institute of Neurological Disorders and Stroke Type: 5P01 NS 11255-24 08/15/96-07/31/06
The long-term objective of Project 1 is to investigate mechanisms whereby a limited midline myelotomy can lead to pain relief in patients suffering from intractable pelvic cancer pain. Our investigation of visceral pain mechanisms led to the discovery of a visceral pain pathway formed by the axons of postsynaptic dorsal column (PSDC) neurons that ascend in the dorsal column (DC) to the dorsal column nuclei. Visceral nociceptive information is then relayed from the dorsal column nuclei to the thalamus and other brain structures. This discovery amounted to a paradigm shift in our understanding of pain pathways and had a tremendous impact on the surgical approach to deal with intractable visceral pain.
3) Institutional Grants:
a) National Institute of Health:
Grant 1: “Institute for Clinical and Translational Science” PI: Philip Kern, MD Elie D. Al-Chaer, MS, PhD, JD: co-Investigator Pending 10% Agency: National Institutes of Health, NCRR Type: U54, CTSA application Role: co-Director of Governance
Grant 2: “Institute for Clinical and Translational Science” PI: Philip Kern, MD Elie D. Al-Chaer, MS, PhD, JD: co-Investigator 09/01/06-08/31/07 20% Agency: National Institutes of Health, NCRR Type: P20, planning application Role: Chair, Planning Team
Grant 3: “The Center for Translational Neuroscience” PI: Edgar Garcia-Rill, PhD Elie D. Al-Chaer, MS, PHD, JD: Member 09/01/04-07/31/09 6% Agency: National Institutes of Health, NCRR Type: COBRE application Role: Mentor
4) Training Grants: Currently not on any one. The ones listed below were at UTMB.
Pre-doctoral Training Grant “Training in Neuroscience” Program Director: James E. Blankenship, Ph.D. Elie Al-Chaer, Ph.D.: Collaborator
Post-doctoral Training Grant “Training in Neurobiology of Pain” Program Director: William D. Willis, M.D., Ph.D. Elie Al-Chaer, Ph.D.: Collaborator
Post-doctoral Training Grant “Basic and Translational GI and Liver Research Training” Program Director: Pankaj J. Pasricha, MD Elie Al-Chaer, Ph.D.: Collaborator ACADEMIC SERVICES / COMMITTEES
National / International:
2008 Co-Chair, NIH Special Emphasis Panel to review Grant Applications on a Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network (U01). 2008 Chair, American Gastroenterological Association (AGA) Research Forum on Animal Models of Functional and Motility Disorders. Digestive Diseases Week, San Diego, CA, May 2008. 2007-2008 Chair, AGA abstract review committee on Animal Models of Functional and Motility Disorders for the Digestive Disease Week (DDW), the annual meeting for all digestive diseases societies in the USA with an international membership. I organize a committee that reviews, evaluates and grades hundreds of abstracts submitted each year and finally selects those worthy of presentation or publication. 2007- Member, NIH Special Emphasis Panel to review Specialized Centers of Interdisciplinary Research (SCOR) on Sex and Gender Factors Affecting Women’s Health (ZRG1 HOP-U). 2007- Member, NIH Grant Application Review Council: Neural Sciences and Disorders (NSD-C). 2005- Member, Advisory Board, International Foundation for Functional Gastrointestinal Disorders. 2005- Member, NIH Grant Application Study Section: Somatosensory/Pain (ZRG1 IFCN-K). 2004 Chair, NIH Special Council on Mind-Body Interactions and Health (ZRG1 RPHB-B 50 R). 2003 Member, NIH Special Emphasis Panel on Behavioral and Social Sciences Research, a special study section to evaluate grant applications for the “Mind-Body Interactions and Health: Research Infrastructure Program”. 2003-05 Member, NIH Grant Application Study Section: Clinical Neuroplasticity and Neurotransmitters (ZRG1 CNNT-01) / Brain Disorders and Clinical Neuroscience (ZRG1 BDCN2). 2003- Invited member, Rome III Multinational Team on Functional Gastrointestinal Disorders Policy: a team of distinguished scientists and clinicians from around the world that meets every 10 years to shape the clinical and research policy of functional disorders for the next decade (Membership by invitation only). Members will co-author ROME III, the third edition of the book on Functional gastrointestinal disorders. 2001-2003 Chair, American Gastroenterological Association (AGA) abstract review committee on Colonic Motility and Disorders for the Digestive Disease Week (DDW), the annual meeting for all digestive diseases societies in the USA with an international membership.
Peer-review services: 2004- Member, reviewer’s board for the journal GUT. 1999- Ad-hoc reviewer for the following journals: Neuroscience, J. Neuroscience, J. Neurophysiology, Brain Research, Experimental Brain Research, Pain, J. Pain, Gastroenterology, Neuro-gastroenterology (since 2003), GUT (since 2003). Ad-hoc reviewer for the National Science Foundation (NSF), the Veterans Administration Health System (VAHS) and the National Student Research Forum (NSRF). Institutional:
UAMS: 2007- Co-Director of Governance: Institute for Clinical and Translational Science (ICTS), UAMS 2006- Director of Planning: Planning phase, Institute for Clinical and Translational Science (ICTS), UAMS 2006- Co-Director: Planning and Development, ICTS, UAMS 2006- Co-Director: Administrative Committee, ICTS, UAMS 2006- Chair, Planning Team, ICTS, UAMS 2006- Member, Executive Committee, ICTS, UAMS 2005- Member, CUMG/Dean Grant review committee 2004- Member, Center for Translational Neuroscience, College of Medicine, UAMS.
UTMB: 2004 Chair, Examination Committee, Neuroscience Graduate Program, Graduate School of Biomedical Sciences, UTMB 2001-2004 Member, Admissions Committee, School of Medicine, UTMB. Review and evaluate hundreds of medical school applications and interview and rank hundreds of applicants every year. 2001-2004 Member, Examination Committee, Neuroscience Graduate Program, Graduate School of Biomedical Sciences, UTMB Oversee the Neuroscience Graduate Program Qualifying Exam, by evaluating the questions, the corrections and the grading. 2001 Coordinator, Seminars and Annual Meeting, Gulf Coast GI Research Forum 2000-2003 Member, Grant Review Committee, the Gastrointestinal Research Interdisciplinary Program (GRIP), UTMB 2000-2003 Member, Seminar Committee, the Gastrointestinal Research Interdisciplinary Program (GRIP), UTMB
Departmental:
2005- Member, Mentoring Committee, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA. 2005- Member, Graduate Advisory Committee, Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA. 2000-2003 Chair, Postgraduate Pain Program Sub-Committee, Department of Anatomy and Neurosciences, UTMB. Objectives: Provide an interactive educational forum for scientists and clinicians interested in Pain management and Research. 1999-2004 Member, Program Project Grant Committee, Pain Group, Department of Anatomy and Neurosciences, UTMB 1998-2002 Webmaster of GI Web, The website development team for the Division of Gastroenterology, UTMB. http://www2.utmb.edu/gastroenterology
Other: GRADUATE STUDENTS EXAM COMMITTEES
I mentored, co-mentored and served on the graduate exam committee of the following students:
2008 Mentor and PhD Thesis Supervisor, UAMS 1) Jennifer Leigh Atchison, MD/PhD student 2) Martin Watts, MD/PhD student
2008 Graduate School External Examiner Hong Kong Baptist University Doctor of Philosophy Degree Programme Student: Zhang Xiaojun Supervisor: Dr. Bian ZhaoXiang Thesis Title: Analgesic Effect of Paeoniflorin in Rats with Visceral Hyperalgesia Induced by Neonatal Maternal Separation
2005-2006 Neuroscience Graduate Program Faculty Examiner, UAMS. Student: Fann, Alice MD (Ph.D. Candidate). Supervisor: Garcia-Rill, Edgar Ph.D. Thesis Title: “Chronic Low Back Pain: Arousal, Attention, and Frontal Lobe Blood Flow Dysfunctions”
2000-2003 Neuroscience Graduate Program Faculty Examiner, UTMB. Student: Vera-Portocarrero, Louis P. (Ph.D. Candidate). Supervisor: Westlund-High, Karin N. Ph.D. Thesis Title: “Descending modulation and visceral pain”
1999-2001 Neuroscience Graduate Program Faculty Examiner, UTMB. Student: Hains, Bryan (Ph.D. Candidate). Supervisor: Hulsebosch, Claire E., Ph.D. Thesis Title: “Transplant therapy and cellular mechanisms contributing to chronic pain after spinal cord injury.”
1999-2001 Neuroscience Graduate Program Faculty Examiner, UTMB. Student: Saab, Carl (Ph.D. Candidate). Supervisor: Willis, William D. M.D., Ph.D. Thesis Title: “Role of the cerebellum in Pain.” Co-Mentored Publications:
1) Saab C.Y., Kawasaki M., Al-Chaer E.D. and Willis, W.D. Cerebellar cortical stimulation increases spinal visceral nociceptive responses. J. Neurophysiol. 85(6): 2359-2363, 2001 2) Saab, C.Y., Kawasaki M., Masaad, C.A., Saadé, N.E., Al-Chaer, E.D. and Willis W.D. Is the cerebellum involved in analgesia or Pain? Society for Neuroscience, 2000 3) Saab C.Y., Kawasaki M, Al-Chaer E.D. and Willis W.D. Cerebellar modulation of spinal nociceptive responses: Can pain be influenced from the cerebellum? American Pain society, 19th Annual Scientific Meeting, Atlanta, Georgia, November 2-5, 2000
TEACHING RESPONSIBILITIES
A. Medical School
2005 - Lecturer, Neuroscience Course, MED I, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA. (Apr., 1 contact hour). 2003 - 2004 Lecturer and Laboratory teacher, Human Neuroscience and Behavior Course, MED I, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. (Spring Term, 50 contact hours) 2000 - 2001 Lecturer, lecture on “Visceral Pain and Irritable Bowel Syndrome” GI and Nutrition Course, MED II, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. (Fall Term, 2 contact hours) 1999 - 2002 Facilitator, Human Neuroscience and Behavior Course, MED I, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. (Spring Term, 50 contact hours per year) 1999 Laboratory instructor, Human Neuroscience and Behavior Course, MED I, Integrated Medical Curriculum, School of Medicine, University of Texas Medical Branch, Galveston, Texas, USA. (Spring Term, 50 contact hours) 1995 Teaching Assistant of Neuroscience, First Year Medical School (MED I), Faculty of Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
B. Graduate School
2007 - Lecturer, Cellular and Developmental Neuroscience, Graduate School, University of Arkansas for Medical Sciences, Little Rock, AR. Two lectures: “Neuroscience of Pain: Mechanisms and Pathways & Syndromes and Modulation” (Spring Term, 3 contact hours) 2006 - Lecturer, Graduate Neuroscience Course, Graduate School, University of Arkansas for Medical Sciences, Little Rock, AR. 1 lecture: “Pain” (Fall Term, 1 contact hour) 2006 - Lecturer, Cellular and Developmental Neuroscience, Graduate School, University of Arkansas for Medical Sciences, Little Rock, AR. Two lectures: “Release of Neurotransmitters” and “Neurotransmitter Receptors” (Spring Term, 3 contact hours) I prepare the lectures and present them to the graduate students taking the Cellular and Developmental Neuroscience Course and the Graduate Neuroscience Course. 2000 - 2004 Course Director and Lecturer, Core Pain Conference (NEUX 6000-013), Neuroscience Graduate Program, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston, Texas, USA. (Fall Term, 20 contact hours) I oversee the admission process, organize and outline the curriculum, invite the participating faculty and monitor the progress and evaluate the conference.
SOCIETIES AND AFFILIATIONS
2006- DC Bar Association, member 2003-04 Galveston County Bar Association, member 2003-04 Galveston County Young Lawyers Association, member 2003- Rome Foundation for Gastrointestinal Disorders, member 2002- Texas Young Lawyers Association, member 2002- American Bar Association (ABA), member 2002- State Bar of Texas, member 2002-04 Chair, American Gastroenterological Association (AGA) committee on Colonic Motility and Disorders. 1998- American Gastroenterological Association (AGA), member 1997- 02 American Bar Association (ABA), student member 1996- American Pain Society (APS), member 1996- American Association for the Advancement of Science (AAAS), member 1995- American Physiological Society, member 1995- International Association for the Study of Pain (IASP), member 1993- Society for Neuroscience, member
LICENSURE INFORMATION
2006 (Feb. 3) – Washington DC Bar, Licensed attorney by the District of Columbia Court of Appeals to practice in all the courts of the District of Columbia. 2002 (Nov. 6) – State Bar of Texas, Licensed attorney and counselor at law by the Supreme Court of Texas to practice in all courts of the State of Texas.
ADDITIONAL INFORMATION
A. HONORS, SCHOLARSHIPS AND AWARDS
Science related honors: 2006 Plenary speaker at the joint conference of the American Gastroenterological Association (AGA) and the British Society of Gastroenterology (BSG), Title of talk: “Neuroplasticity in visceral pain”, Cambridge, UK. 2003 Plenary speaker, professional development course, the British Society of Gastroenterology 2003 Plenary speaker, Spring Brain Conference, Title of talk: “The role of the dorsal columns in pain states” Sedona, AZ, USA. 2002 Invited speaker on “The art and science of visceral pain: from neonatal plasticity to adult perception” the Pain Research Center, the Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. 2002 Invited to evaluate a $7.5 Million Program Project Grant and to speak on“Plasticity of visceral pain circuitry in adult rats with neonatal colon injury”, Pain Program, University of Maryland Dental School, Baltimore, MD, USA. 2000 The John C. Liebeskind Early Career Scholar Award, for exceptional accomplishment and promise in pain scholarship, American Pain Society 1999 Outstanding Educator Award, Generalist Physician Investigator Program, UTMB 1996 The Mustard Seed Award in Research for outstanding research and service in cancer pain, offered by the Sealy Society 1995 Who’s Who Among Students in American Universities and Colleges 1990 Diana Tamari Sabbagh (DTS) Award for outstanding researchers in medical sciences
Law related awards: 2001 Phi Beta Phi, International Legal Fraternity, Highest Grade award In International Law. 2001 Who’s Who among American Law Students 1999-2002 Dean’s Honor List, South Texas College of Law 1999 Invited to write for Law Review, South Texas College of Law 1997 Outstanding Academic Achievement, 1st Term, South Texas College of Law
Other awards: 1985 AUB scholarship for an outstanding undergraduate student
B. INVITED SPEAKER
2007 (Apr) “Neuroplasticity and Functional Pain” plenary lecture for the 7th International Symposium on Functional Gastrointestinal Disorders, Milwaukee, WI, USA 2007 (Apr) “Pain Pathways” workshop for the 7th International Symposium on Functional Gastrointestinal Disorders, Milwaukee, WI, USA 2006 (Oct) “Visceral Pain: Reflections on Phylogeny, Physiology and Pathways” distinguished lecture: The Oklahoma Center for Neuroscience and the Department of Physiology, Oklahoma University Health Science Center, Oklahoma City, OK, USA. 2006 (Sep) “Visceral Pain: The Rhapsody of a Nervous System”, invited speaker, Queen Mary, University of London and The Royal London Hospital, London, England, UK. 2006 (Sep) “Neuroplasticity in Visceral Pain” plenary lecture given at the joint conference of the American Gastroenterological Association (AGA) and the British Society for Gastroenterology, Cambridge University, England, UK. 2006 (Jul) “Animals Models of Visceral Pain” plenary lecture for the Brain-Gut Symposium held at St. Anne’s College, Oxford University, Oxford, England, UK. 2005 (June) “Functional Pain: the Rhapsody of a Nervous System” invited speaker, The University of Florida Comprehensive Center for Pain Research and the College of Dentistry Dean’s Seminar Series, University of Florida, Gainesville, FL, USA. 2005 (Mar) “Behavioral and Neural Changes in Adult Rats Exposed to Neonatal Colon Injury” invited Physiology seminar, Department of Physiology, College of Medicine, UAMS. 2005 (Feb) “Pain: Reflections on Phylogeny, Physiology and Pathways” Invited Neurology Grand Rounds, Department of Neurology, College of Medicine, UAMS 2005 (Jan) “Visceral Pain: Mechanisms, Pathways and Surgical Solutions” Invited Neurosurgery Grand Rounds, Department of Surgery, College of Medicine, UAMS 2005 (Apr) “Neuroplasticity and Functional Pain” plenary lecture for the 6th International Symposium on Functional Gastrointestinal Disorders, Milwaukee, WI, USA 2005 (Apr) “Pain Pathways” workshop for the 6th International Symposium on Functional Gastrointestinal Disorders, Milwaukee, WI, USA 2003 (Nov) “Neonatal injury: an etiology of functional pain in adults” invited presentation at the Arkansas Children’s Hospital and the Department of Pediatrics at the University of Arkansas Medical School, Little Rock, AR, USA. 2003 (May) Co-Chair and Speaker, Symposium on Central Sensitization, Title of talk: “Animal models of sensitization” Digestive Diseases Week 2003, Orlando, FL, USA. 2003 (May) Guest Speaker, Grand Rounds, Title of Talk: “A beginning in pain and the road to perdition” Department of Anesthesiology, UTMB, Galveston, TX, USA 2003 (Mar.) Invited Plenary Speaker, Professional Postgraduate Development Course on “Stress and the Gut” - British Society of Gastroenterology, Title of talk: “Neonatal stressors and adult visceral hypersensitivity in GI disease” invited seminar for a Birmingham, UK. 2003 (Mar.) Pleanry Speaker, Spring Brain Conference, Plenary Session III, Title of talk: “The role of the dorsal columns in pain states” Sedona, AZ, USA. 2003 (Feb.) Guest Speaker, The Pain Advisory Board for Allergan Inc, Title of Talk: “Pharmacological validation of an animal model of chronic functional abdominal pain” Irvine, CA, USA. 2002 (Sep.) Moderator, Symposium on Basic Science – American Motility Society. Galveston, TX, USA. 2002 (June) “The art and science of visceral pain: from neonatal plasticity to adult perception” invited presentation at the Pain Research Center, the Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. 2002 (Apr) “Chronic abdominal pain: the ghost of a painful past” invited presentation at the Spring Pain Research Conference, Grand Cayman, British West Indies. 2002 (Apr) “Functional bowel disorders in an animal model of chronic visceral pain” a GlaxoSmithKline/Cambridge University Symposium, Harlow, UK. 2002 (Mar) “Neural plastic changes initiated by neonatal injury: the culprit in chronic visceral pain” Symposium organized by the National Institute of Health: Oral, craniofacial and persistent deep pain, Baltimore, MD, USA. 2002 (Mar.) “Plasticity of visceral pain circuitry in adult rats with neonatal colon injury” invited presentation, Pain Program, University of Maryland Dental School, Baltimore, MD, USA. 2001 (Nov) “Biological Basis of Abdominal Pain” an invited lecture given at the 2nd Annual International Course and Workshop On Gastrointestinal Motility/Functional Disorders. TX, USA. 2001 (Sep) “Painful neonatal memories and functional bowel disorders” an invited lecture given at the 18th International Symposium on Neurogastroenterology and Motility. Madison, Wisconsin, USA. 2001 (July) “On the Journey of Pain: from Gut to Brain” an invited lecture given at the “2001: A Brain-Gut Odyssey” meeting of the International Society for Brain-Gut Studies. Oxford, UK. 2001 (May) “Rat Model of Persistent Visceral Hyperalgesia Following Early Life Gut Irritation” an invited lecture at a research symposium entitled “Evolving Animal Models for Functional Gastrointestinal Disorders” Digestive Diseases Week, 2001. GA, USA. 2001 (April) “Chronic Abdominal Pain: The Wounds That Never Heal” an invited lecture given at CURE, University of California at Los Angeles, CA, USA. 2000 (Dec) “The Pathogenesis of Visceral Hyperlagesia.” an invited lecture given at the 1st Annual International Course on Motility and Functional Bowel Disorders. TX, USA. 1999 (Oct) “Pathogenesis, pathways and processing of colon pain: a “state of the science” address.” A symposium for the American Pain Society annual meeting, FL, USA. 1999 (Oct) “Pain Research - On the Threshold of a New Millennium.” Invited lecture for the Society for Neuroscience annual meeting, FL, USA. 1996 (Feb) “The role of the dorsal column in visceral pain” Invited talk given at the University of Oklahoma, Health Sciences Center, OK, USA.
C. MAKING NEWS
My research was featured in a number of magazines and broadcasts around the world including:
2006: Interviewed on the live broadcast of Voice of America’s (VOA) daily international radio discussion “Talk to America”, Nov. 14, 2006, on the topic of Pain. "Talk to America" is the world's only international daily call-in/discussion program, broadcast in English Monday through Friday and aired over VOA's global short-wave transmitter network, as well via satellite, local radio stations overseas and the Internet. http://www.voanews.com/talk. 2005: Featured 3 times in “the Buzz” (Aug, Sep and Nov), a UAMS Newsletter. 1999: Interviewed by Science News for an article entitled “Pain, Pain, Go Away” Science News 155: 108-110, February 1999. 1999: Interviewed by BioPhotonics International for an article entitled “Functional MRI shows pathway for visceral pain” BioPhotonics International pp. 26-28, March/April 1999. 1999: Featured in the UTMB Quarterly in an article entitled “Pain, Pain, Go Away” UTMB Quarterly, pp. 18-21, Fall 1999. 1999: Interviewed by the British Broadcasting Corporation (BBC), Science Department, for a program entitled BBC Horizon on October 07, 1999. 1999: Interviewed by Medscape, CBS on October 23rd, 1999. 1998: Interviewed by IMPACT (UTMB Newsletter) for an article entitled “Researchers determine how gut pain affects the brain. IMPACT 22 (20): 3, November 16, 1998. 1998: Interviewed by Radiology and Imaging Letter for a Feature Article entitled “Researchers use Brain fMRI to find New Pathway to Resolve Pelvic Pain.” RIL 18 (21): 163 – 165, December 1, 1998. 1996: Featured in the Galveston County Daily News under “UTMB Society awards 5 for services” The Galveston County Daily News 154 (61): 7-A, Monday June 10, 1996. 1996: Featured in IMPACT (UTMB Newsletter) as the recipient of the Sealy Society Mustard Seed Award in Research for 1995. IMPACT 20 (12): 1-2, June 17, 1996. 1988: Interviewed by “Le Nouveau Magazine” (weekly political, economical and cultural Middle Eastern magazine in French) for an article entitled “Le Club Culturel de L’OCP en mission diplomatique.” Le Nouveau Magazine No. 1591, January 30 1988.
D. PROFESSIONAL CONSULTANT2005- Member, Advisory Board, International Foundation for Functional Gastrointestinal Disorders (IFFGD), USA.2004- Member, Visceral Pain Advisory Board, Allergan Inc, Irvine, CA, USA2003-2004 Strategic consultant, Governing Board, Sigma Health Care, Inc. Galveston, TX, USA2003- Member, Pain Advisory Board, Allergan Inc, Irvine, CA, USA 2000-2004 Member, Professional Advisory Committee, Sigma Health Care, Inc. Galveston, TX, USA1999- Biomedical research professional consultant, Allergan Inc, Irvine CA, USA
E. SEMINARS AND SYMPOSIA (Comprehensive List)
2008 (Apr) Invited speaker, Rural Hospital Program, Title of Talk: “Pain: a Primer on Neural Mechanisms and Management” (satellite broadcast) Little Rock, AR, USA. 2007 (Apr) Invited plenary speaker, the 6th International Symposium on Functional Gastrointestinal Disorders, Title of Talk: “Neuroplasticity and Functional Pain” Milwaukee, WI, USA 2007 (Apr) Invited workshop, the 6th International Symposium on Functional Gastrointestinal Disorders, Title of workshop: “Pain Pathways” Milwaukee, WI, USA 2006 (Oct) Distinguished lecture, the Oklahoma Center for Neuroscience and the Department of Physiology, Oklahoma University Health Science Center. Title of talk: “Visceral Pain: Reflections on Phylogeny, Physiology and Pathways”, Oklahoma City, OK, USA. 2006 (Sep) Invited Speaker, Queen Mary, University of London and The Royal London Hospital, Title of Talk: “Visceral Pain: The Rhapsody of a Nervous System”, invited speaker, London, England, UK. 2006 (Sep) Plenary lecture, the joint conference of the American Gastroenterological Association (AGA) and the British Society for Gastroenterology. Title of talk: “Neuroplasticity in Visceral Pain”, Cambridge University, England, UK. 2006 (Jul) Plenary lecture, the Brain-Gut Symposium held at St. Anne’s College, Oxford University. Title of talk: “Animals Models of Visceral Pain”, Oxford, England, UK. 2005 (June) Invited Speaker, The University of Florida Comprehensive Center for Pain Research and the College of Dentistry Dean’s Seminar Series, Title of talk: “Functional Pain: the Rhapsody of a Nervous System” The University of Florida, Gainesville, FL, USA. 2005 (Apr) Invited plenary speaker, the 6th International Symposium on Functional Gastrointestinal Disorders, Title of Talk: “Neuroplasticity and Functional Pain” Milwaukee, WI, USA 2005 (Apr) Invited workshop, the 6th International Symposium on Functional Gastrointestinal Disorders, Title of workshop: “Pain Pathways” Milwaukee, WI, USA 2005 (Mar) Invited Physiology Seminar, Title of talk: “Behavioral and Neural Changes in Adult Rats Exposed to Neonatal Colon Injury” Department of Physiology, College of Medicine, UAMS. 2005 (Feb) Invited Neurology Grand Rounds, Title of talk: “Pain: Reflections on Phylogeny, Physiology and Pathways” Department of Neurology, College of Medicine, UAMS 2005 (Feb) Seminar, “Pain: the Rhapsody of a Nervous System” Pain Arkansas Club, UAMS 2005 (Jan) Invited Neurosurgery Grand Rounds, Title of talk: “Visceral Pain: Mechanisms, Pathways and Surgical Solutions” Department of Surgery, College of Medicine, UAMS 2003 (Nov) Guest Speaker, The Arkansas Children’s Hospital and the Department of Pediatrics at the University of Arkansas Medical School, Title of talk: “Neonatal injury: an etiology of functional pain in adults” Little Rock, AR, USA. 2003 (May) Invited Chair and Speaker, Symposium on Central Sensitization, Title of talk: “Animal models of sensitization” Digestive Diseases Week 2003, Orlando, FL, USA. 2003 (Mar.) Invited Plenary Speaker, Postgraduate Professional Development Course - British Society of Gastroenterology, Title of talk: “Neonatal stressors and adult visceral hypersensitivity in GI disease” Birmingham, UK. 2003 (Mar.) Invited Plenary Speaker, Spring Brain Conference, Plenary Session III, Title of talk: “The role of the dorsal columns in pain states” Sedona, AZ, USA. 2003 (Feb.) Guest Speaker, The Pain Advisory Board for Allergan Inc, Title of Talk: “Pharmacological validation of an animal model of chronic functional abdominal pain” Irvine, CA, USA. 2002 (Sep.) Moderator, Symposium on Basic Science – American Motility Society. Galveston, TX, USA. 2002 (June) Guest Speaker, The Pain Research Center at the Brigham and Women’s Hospital, Harvard University. Title of talk: “The art and science of visceral pain: from neonatal plasticity to adult perception” Boston, MA, USA. 2002 (April) Speaker, The Spring Pain Research Conference. Title of talk: “Chronic abdominal pain: the ghost of a painful past” Grand Cayman, British West Indies. 2002 (April) Speaker, GlaxoSmithKline/Cambridge University Symposium. Title of talk: “Functional bowel disorders in an animal model of chronic visceral pain” Harlow, UK. 2002 (Mar.) Speaker, NIH Symposium: Oral, Craniofacial and Persistent Deep Pain. Title of talk: “Neural plastic changes initiated by neonatal injury: the culprit in chronic visceral pain” Baltimore, MD, USA. 2002 (Mar.) Guest Speaker, University of Maryland Dental School, Pain Program. Title of talk: “Plasticity of visceral pain circuitry in adult rats with neonatal colon injury” Baltimore, MD, USA. 2001 (Nov.) Speaker, The 2nd Annual International Course and Workshop On Gastrointestinal Motility/Functional Disorders. Title of talk: “Biological Basis of Abdominal Pain” Galveston, TX, USA. 2001 (Sep.) Speaker, The 18th International Symposium on Neurogastroenterology and Motility. Title of talk: “Painful neonatal memories and functional bowel disorders” Madison, Wisconsin, USA. 2001 (July) Speaker, “2001: A Brain-Gut Odyssey” meeting of the International Society for Brain-Gut Studies. Title of talk: “On the Journey of Pain: from Gut to Brain” University of Oxford, Oxford, UK. 2001 (May) Speaker, “Evolving Animal Models for Functional Gastrointestinal Disorders” a research symposium at the Digestive Diseases Week, 2001. Title of talk: “Rat Model of Persistent Visceral Hyperalgesia Following Early Life Gut Irritation” Atlanta, GA, USA. 2001 (April) Speaker, Seminar series at CURE, University of California at Los Angeles. Title of talk: “Chronic Abdominal Pain: The Wounds That Never Heal” Los Angeles, CA, USA. 2000 (Dec.) Speaker, International Course on Motility and Functional Bowel Disorders. Title of talk: “The Pathogenesis of Visceral Hyperlagesia.” Galveston, TX, USA. 2000 (Dec.) Coordinator and Speaker, Symposium on Gastrointestinal Pain. Title of talk: “An Animal Model of IBS: The Key to the Puzzle in a Long Abandoned Challenge?” University of Texas Medical Branch, Galveston, TX, USA. 2000 (Nov.) Chair and Speaker, Professional Development Course for the American Pain Society, Atlanta, GA, USA. Title of talk: “Management of chronic visceral pain: an overview of basic research, psychophysics, symptoms, treatments and social correlates.” 1999 (Oct.) Chair and Speaker, Symposium for the American Pain Society, Ft. Lauderdale, FL: “Pathogenesis, pathways and processing of colon pain: a “state of the science” address.” 1999 (Oct.) Speaker, Lecture for the Society for Neuroscience, “Pain Research - On the Threshold of a New Millennium.” Miami, FL. 1999 (May) Speaker, Seminar given for the Neuroscience Graduate Program, University of Texas Medical Branch, Title of talk: “Ode to an Empty Bowel” Galveston, Texas. 1998 (May) Speaker, Seminar, Digestive Disease Week 98, Title of talk: “A quantitative basis for the dorsal column dominant role in visceral pain”. New Orleans, LA, USA. 1996 (Oct.) Speaker, Dissertation Defense Seminar, Dept. of Anatomy and Neurosciences, University of Texas Medical Branch, Title of talk: “The role of the dorsal column in visceral pain”; Galveston, Texas, USA. 1996 (Feb.) Speaker, Seminar given at the University of Oklahoma, Health Sciences Center. Title of talk: “The role of the dorsal column in visceral pain” Oklahoma City, OK 1995 (Jan.) Speaker, Dissertation Proposal seminar for the degree of Doctor of Philosophy, Dept. of Anatomy and Neurosciences, UTMB, “Visceral input into the ventral posterolateral nucleus of the thalamus: a pathway in the fasciculus gracilis involving the postsynaptic dorsal column system” Galveston, Texas, USA 1994 (Aug.) Speaker, Seminar given at the Dept. of Anatomy and Neurosciences, UTMB, title of talk: “Viscero-somatic interactions in the thalamus: a possible role of the dorsal column” Galveston, Texas, USA 1991 (July) Speaker, Dissertation Defense seminar for the degree of Master of Sciences, Dept. of Physiology, Faculty of Medicine, AUB. Title of talk: “Dorsal column input into the nucleus locus coeruleus” Beirut, Lebanon 1990 (June) Speaker, Seminar given at the dept. of Physiology, AUB. Title of talk: “The role of the nucleus locus ceoruleus in antinociception” Beirut, Lebanon
PUBLICATIONS
PUBLISHED
A. Articles in Peer-reviewed journals
1. Al-Chaer, E.D., Lawand, N.B., Westlund, K.N. and Willis, W.D. Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus: a new function of the dorsal column. J. Neurophysiol. 76:2661-2674, 1996.
2. Al-Chaer, E.D., Lawand, N.B., Westlund, K.N. and Willis, W.D. Pelvic visceral input into the nucleus gracilis is largely mediated by the postsynaptic dorsal column pathway. J. Neurophysiol. 76: 2675-2690, 1996.
3. Hirshberg, R.M., Al-Chaer, E.D., Lawand, N.B. Westlund, K.N. and Willis, W.D. Is there a pathway in the dorsal funiculus that signals visceral pain? Pain 67:291-305, 1996.
4. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. Potentiation of thalamic responses to colorectal distension by visceral inflammation. NeuroReport 7:1635-1639, 1996.
5. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. The dorsal column: A possible role in visceral hyperalgesia. In Jensen, T.S., Turner, J.A. and Wiesenfield-Hallin, Z. (ed): Proceedings of the 8th world congress on pain, vol. 8, 1997, pp. 839-853.
6. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. The nucleus gracilis: an integrator for visceral and somatic information. J. Neurophysiol. 78:521‑527, 1997.
7. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. Effects of colon inflammation on the responses of postsynaptic dorsal column cells to visceral and cutaneous stimulation. NeuroReport 8: 3267-3273, 1997.
8. Al-Chaer, E.D., Feng, Y. and Willis, W.D. A role for the dorsal column in nociceptive visceral input into the thalamus of primates. J. Neurophysiol. 79 (6): 3143-3150, 1998.
9. Feng, Y., Cui, M., Al-Chaer, E.D. and Willis, W.D. Epigastric antinociception by cervical dorsal column lesion in rats. Anesthesiology 89 (2): 411-420, 1998.
10. Al-Chaer, E.D., Feng, Y. and Willis, W.D. A comparative study of viscerosomatic input onto postsynaptic dorsal column and spinothalamic tract neurons in the primate. J. Neurophysiol. 82 (4):1876-1882, 1999.
11. Willis, W.D., Al-Chaer, E.D., Quast, M. J. and Westlund, K. N. A visceral pain pathway in the dorsal column of the spinal cord. In: The Neurobiology of Pain. By: The National Academy of Sciences (USA). PNAS 96 (14): 7675-7679, 1999.
12. Saab C.Y., Makki A., Quast M., Wei J., Al-Chaer E.D., Willis W.D. Is the cerebellum involved in pain? In: Proceedings of the 9th World Congress on Pain, vol 16. IASP Press, Seattle, pp 515–522, 2000.
13. Al-Chaer, E.D., Kawasaki, M. and Pasricha, P.J. A new model of chronic visceral hypersensitivity: in adult rats induced by colon irritation during postnatal development. Gastroenterology 119: 1276–1285, 2000.
14. Saab C.Y., Kawasaki M., Al-Chaer E.D. and Willis, W.D. Cerebellar cortical stimulation increases spinal visceral nociceptive responses. J. Neurophysiol. 85(6): 2359-2363, 2001.
15. Zhang, H.Q., Al-Chaer, E.D. and Willis, W.D. Effect of tactile inputs on thalamic responses to noxious colorectal distension in rat. J. Neurophysiol. 88:1185-1196, 2002.
16. Zhang, H.Q., Rong, P.J., Zhang, S.P., Al Chaer, E.D. and Willis, W.D. Noxious visceral inputs enhance cutaneous tactile responses in rat thalamus. Neurosci. Lett. 336:109-112, 2003.
17. Lin, C. and Al-Chaer, E.D. Long-term sensitization of primary afferents in adult rats exposed to neonatal colon pain. Brain Res. 971: 73-82, 2003.
18. Kawasaki, M. and Al-Chaer, E.D. Intradermal capsaicin inhibits lumbar dorsal horn neuronal responses to colorectal distension. NeuroReport 14 (7): 985-9, 2003.
19. Arai, Y-C.P., Ueda, W. and Al-Chaer, E.D. Pre-anesthetic maternal separation increases pups' locomotor behavior during emergence from anesthesia in rats. Acta Anaesthesiol Scand 48: 174-177, 2004.
20. Saab, C.Y., Arai, Y-C.P. and Al-Chaer, E.D. Modulation of visceral nociceptive processing in the lumbar spinal cord following thalamic stimulation or inactivation and after dorsal column lesion in rats with neonatal colon irritation. Brain Res. 1008 (2): 186-192, 2004.
21. Arai, Y-C.P., Ueda, W and Al-Chaer, E.D. Pre-anesthetic presence of an injured dam influences pups’ locomotor behavior during emergence from anesthesia in rats. Acta Anaesthesiol Scand 49: 166-169, 2005.
22. Lin, C and Al-Chaer, E.D. Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model. World J Gastroenterol 41:6495-6502, 2005.
23. Grundy, D., Al-Chaer, E.D., Aziz, Q., Collins, S.M., Ke, M., Tache, Y., Wood, J.D. Fundamentals of neurogastroenterology: basic science. Gastroenterology 130(5):1391-1411, 2006.
24. Saab, C.Y., Wang J., Gu, C., Garner, K.N. and Al-Chaer, E.D. Microglia: A newly discovered role in visceral hypersensitivity? Neuron Glia Biology 2: 271-277, 2006.
25. Hayar A.M., Gu C. and Al-Chaer E.D. An improved method for patch clamp recording and calcium imaging of neurons in the intact dorsal root ganglion in rats. J. Neurosci. Methods 173(1): 74-82, 2008.
26. Wang, J., Gu, C. and Al-Chaer, E.D. Altered behavior and digestive outcomes in adult male rats primed with minimal colon pain as neonates. Behav Brain Funct. 4(1): 28, 2008.
B. REVIEWS
1. Al-Chaer, E.D., Feng, Y. and Willis, W.D. Visceral pain: a disturbance in the sensorimotor continuum? Pain Forum 7 (3): 117-125, 1998.
2. Al-Chaer, E.D. and Traub R.J. Biological basis of visceral pain: recent developments. Pain 96: 221-225, 2002.
3. Grundy D, Al-Chaer ED, Aziz Q, Collins SM, Ke M, Tache Y, Wood JD. Fundamentals of neurogastroenterology: basic science. Gastroenterology 130(5):1391-1411, 2006.
C. ARTICLES SUBMITTED / IN PRESS
Wang, J., Gu, C., Garner K.N. and Al-Chaer, E.D. Sex differences in the processing of viscerosensory information.
D. OTHER (BOOK CHAPTERS)
1. Willis, W.D., Al-Chaer, E.D., Quast, M. J. and Westlund, K. N. Evidence for the presence of a visceral pain pathway in the dorsal column of the spinal cord. In Somatosensory processing: from single neuron to brain imaging. Editors: Rowe, M.J. and Iwamura Y. pp. 51-75, 2001. Harwood Academic Publishers, Amsterdam, The Netherlands.
2. K. J. S. Anand, A. T. Bhutta, R. W. Hall, C. R. Rovnaghi, and E. D. Al-Chaer. Long-term effects of repetitive pain in the neonatal period: neuronal vulnerability, imprinting, and plasticity. In Neonatal Pain, Hodgson DM (Ed), Section IV, Chapter 15, pp. 197 – 210, Taylor and Francis Medical Books, London, 2005.
3. Al-Chaer, E.D. Descending Modulation of Visceral Pain. In Descending Modulation of Spinal Nociceptive Processing. Section Editor: Ronald Dubner. Encyclopedia of Pain. Schmidt R. and Willis W.D. Springer-Verlag, Heidelberg, Germany, 2006, pp. 576-578.
4. Al-Chaer, E.D. Visceral Pain / Irritable Bowel Syndrome Model. In Animal Models and Experimental Tests to Study Nociception and Pain. Section Editor: Jin Mo Chung. Encyclopedia of Pain. Schmidt R. and Willis W.D. Springer-Verlag, Heidelberg, Germany, 2006, pp. 2623-2626.
5. Wood JD, Grundy D, Al-Chaer ED, Aziz Q, Collins SM, Ke M, Tache Y. Fundamentals of neurogastroenterology: basic science. In ROME III, The Functional Gastrointestinal Disorders, 3rd Ed. (Drossman et al. Eds.), Degnon Associates, Inc. McLean, VA, pp. 31-88, 2006.
6. Al-Chaer, E.D. Postsynaptic Dorsal Column Neurons, Responses to Visceral Input. In Ascending Transmission of Nociceptive Signals. Section Editor: Glenn J. Giesler Jr. Encyclopedia of Pain. Schmidt R. and Willis W.D. editors. Springer-Verlag, Heidelberg, Germany, 2006, pp. 1954-1956.
7. Al-Chaer, E.D. and Willis W.D. Neuroanatomy of visceral pain: Pathways and processes in “Chronic abdominal and visceral pain: theory and practice” PJ Pasricha, WD Willis and GF Gebhart (Eds), Chapter 4, pp. 33-44, Informa Health Care, Inc. New York, NY, 2007.
8. Anand KJS, Al-Chaer ED, Bhutta AT and Hall RW. Development of Supraspinal Pain Processing. In: 3rd Edition of “Pain in Neonates & Infants” (Anand, Stevens, McGrath Eds.) Pain Research and Clinical Management, Chapter 3, Elsevier Churchill-Livingstone, Edinburgh, pp. 25-44, 2007.
10. Al-Chaer, E.D. and Hyman, P.E. Visceral pain in infancy, In: 3rd Edition of “Pain in Neonates & Infants” (Anand, Stevens, McGrath Eds.) Pain Research and Clinical Management, Chapter 14, pp. 201-210, Elsevier Churchill-Livingstone, Edinburgh, 2007.
11. Al-Chaer, E.D. Neuropathic Visceral Pain. In “Mechanisms of Pain in Peripheral Neuropathy” Eds. Maxim Dobrestov and Jun Ming Zhang, 2008.
12. Al-Chaer, E.D. Pain Pathways, In “Biobehavioral Approaches to Pain” Ed. Rhonda J. Moore, Springer, 2008.
E. ABSTRACTS
1. Jabbur, S.J., El-Chaer, E., Atweh, S.F. and Saadé, N.E. Activation of locus coeruleus neurons by dorsal column (DC) stimulation (st). Society for Neuroscience Abstracts, 1991, 17:292.
2. Al-Chaer, E.D., Saadé,N.E., Atweh, S.F. and Jabbur, S.J. Dorsal column input into the nucleus locus ceoruleus in cat. Lebanese Association for the Advancement of Science Abstracts, 1992, 11:194.
3. Jabbur, S.J., Atweh, S.F., Al-Chaer, E.D. and Saadé, N.E. Modulation of discharges of cuneate neurons (CN) by conditionning stimuli to the lateral and medial vestibular nuclei. Society for Neuroscience Abstracts, 1993, 19:329.
4. Rees, H., Tsuruoka, M., Al-Chaer, E.D. and Willis, W.D. Excitation and inhibition of STT cells by stimulation of the pretectal region in the anesthetized primate. J. Physiol. Proc. 4760: 47, 1994.
5. Al-Chaer, E.D., Rees, H., Tsuruoka, M. and Willis, W.D. Facilitation of superficial STT cells by stimulation of the pretectal region in the primate. Society for Neuroscience Abstracts, 1994, 20:548.
6. Hirshberg, R.M., Al-Chaer, E.D., Lawand, N.B., Westlund, K.N. and Willis, W.D. Is there a pathway in the dorsal funiculus that signals visceral pain? 10th European Congress of Neurosurgery Abstracts, Berlin 1995.
7. Al-Chaer, E.D., Lawand, N.B., Westlund, K.N. and Willis, W.D. The dorsal column is more important for visceral pain than the spinothalamic tract? Society for Neuroscience Abstracts, 1995, 21:644.
8. Lawand, N.B., Al-Chaer, E.D., Westlund, K.N. and Willis W.D. Administration of morphine and CNQX in the rat sacral cord blocks the responses of dorsal column nuclei (DCN) cells to visceral but not to cutaneous stimulation. Society for Neuroscience Abstracts, 1995, 21:644. 9. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. The dorsal column: a possible role in visceral hyperalgesia. International Association for the Study of Pain Abstracts, 1996
10. Westlund, K.N., Hirshberg, R.M., Lawand, N.B., Al-Chaer, E.D. and Willis, W.D. Anatomical evidence for a visceral pain pathway in the dorsal column. International Association for the Study of Pain Abstracts, 1996
11. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. Modulation of viscero-somatic interactions in the thalamus by dorsal column input. Society for Neuroscience Abstracts, 1996.
12. Westlund, Al-Chaer, E.D. and Willis, W.D. The nucleus gracilis (NG): a cross road for pelvic visceral and cutaneous inputs into the thalamus. Society for Neuroscience Abstracts, 1996.
13. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. Effects of colon inflammation on neuronal responses to colorectal distension and cutaneous stimuli. Gulf Coast GI Research Forum, 1996. 14. Rees, H., Houghton, K.A. Chen, P.-S., Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. Anterior pretectal inhibition is blocked by spinal administration of strychnine but not blocked by "2-adrenoceptor antagonists in the anaesthetized primate . J. Physl. Lon. 4950: 20, 1996.
15. Al-Chaer, E.D., Feng, Y., Westlund, K.N. and Willis, W.D. The dorsal column: a role in nociceptive viscerosensory processing in the primate. Society for Neuroscience Abstracts, 1997.
16. Lawand, N.B., Al-Chaer, E.D., Willis W.D. and Westlund, K.N. Metabotropic glutamate receptors in the knee joint: a possible role in peripheral sensitization. Society for Neuroscience Abstracts, 1997.
17. Willis, W.D., Westlund, K.N. and Al-Chaer, E.D. Spinal pathways for colorectal input into the solitary nucleus. Society for Neuroscience Abstracts, 1997.
18. Chen, P.S., Houghton, A.K., Al-Chaer, E.D., Westlund, K.N. and Willis, W.D. Responses of primate STT cells and rat dorsal horn cells to noxious cutaneous mechanical and thermal stimulation are inhibited by chemical stimulation of the anterior pretectal nucleus. Society for Neuroscience Abstracts, 1997.
19. Al-Chaer, E.D., Feng, Y., Westlund, K.N. and Willis, W.D. Visceral pain in the primate: a pathway in the dorsal column. Gulf Coast GI Research Forum, 1997.
20. Al-Chaer, E.D., Feng, Y., Wei, J., Gondesen, K., Willis, W.D. and Quast M. Brain activity during noxious visceral stimulation. Experimental Biology 1998 (FASEB).
21. Quast, M.J., Al-Chaer, E.D., Wei, J., Feng, Y., Illangasekare, N., Gonzalez, J.M., Deyo, D., Sell, S., Gondesen, K.J. and Willis, W.D. High resolution fMRI in a monkey model of visceral pain. International Society for Magnetic Resonance in Medicine, 1998.
22. Al-Chaer, E.D. and Willis, W.D. Peripheral muscarinic receptors: a role in neuronal sensitization associated with colon inflammation. American Pain Society Abstracts, 1998.
23. Al-Chaer, E.D., Quast M., Feng, Y., Wei, J., Gondesen, K. Illangasekare, N., Deyo, D. and Willis, W.D. Visceral pain: an asymmetric function of the brain? Neurosci. Abstr. 24, p. 1389, 1998.
24. Al-Chaer, E.D., Feng, Y. and Willis, W.D. Quantitative basis for the dorsal column dominant role in visceral pain in the primate. Digestive Diseases Week Abstract, p A-900, 1998.
25. Winston, J., Shenoy, M., Micci, M.A., Toma, H., Al-Chaer, E.D., Hellmich, Embesi, H. J. and Pasricha, P.J. Tumor necrosis factor-a sensitizes primary neonatal sensory neurons in culture: the potential role of NF-kB in nociception. Gastroenterology 116 (4): G2854.
26. Al-Chaer, Elie D. and Pasricha, P.J. Transient colorectal irritation in the neonatal period produces long lasting visceral sensitization in rats: a potential model for IBS and other painful functional bowel disorders. Gastroenterology 116 (4): G4139.
27. Lu, C.L., Winston, J., Shenoy, M., Hellmich, H., Al-Chaer, Elie D., Saban, R., Saban, M., Lai, C.R. and Pasricha, P. J. Changes in neurotransmitter levels and gene expression after noxious mechanical stimulation of the rectum. Gastroenterology 116 (4): G4486.
28. Al-Chaer, E.D., Quast M., Feng, Y., Wei, J., Gondesen and Willis, W.D. Brain imaging of the long term effect of a midline myelotomy on the processing of visceral and somatic pain using fMRI. Ninth World Congress on Pain, Abstracts, p. 391, IASP Press, Vienna, Austria 1999.
29. Pasricha, P.J. and Al-Chaer, E.D. Neonatal colon irritation produces long lasting visceral hyperalgesia: a potential model for IBS in rats. Ninth World Congress on Pain, Abstracts, p. 392, IASP Press, Vienna, Austria 1999.
30. Saab, C.Y., Makki, A. A., Quast, M. J., Wei, J., Al-Chaer, E. D. and Willis, W. D. Is the cerebellum involved in pain? Ninth World Congress on Pain, Abstracts, p. 174, IASP Press, Vienna, Austria 1999.
31. Al-Chaer, E.D. and Pasricha, P.J. Recurring visceral hyperalgesia is mediated by a dynamic neural exchange along a dorsal horn – thalamus sensitized axis: a new model of IBS in rats. Society for Neuroscience, 29th Annual Meeting, Ft. Lauderdale, FL. Abstracts, p. 400, 1999.
32. Saab, C., Makki, A., Quast, M. J., Wei, J., Al-Chaer, E. D. and Willis, W. D. What might be the implications of pain processing by the cerebellum? Society for Neuroscience, 29th Annual Meeting, Ft. Lauderdale, FL. Abstracts, p. 145, 1999.
33. Zhang, H.Q., Al-Chaer, E.D., W.D. Willis and Chen, P.S. Electrophysiological evidence for referred pain in colorectal distension in rat. Society for Neuroscience, 29th Annual Meeting, Ft. Lauderdale, FL. Abstracts, p. 145, 1999.
34. Al-Chaer, Elie D. and Pasricha, P.J. A new animal model for chronic visceral hyperalgesia in rats. American Pain Society, 18th Annual Scientific Meeting, Program Book, p. 187, 1999.
35. Zhang, H.Q., W.D. Willis and Al-Chaer, E.D. Interactions between vibrotactile skin stimulation and colorectal pain. American Pain Society, 18th Annual Scientific Meeting, Program Book, p. 165, 1999.
36. Saab C.Y., Quast M.J., Wei J.N., Makki A., Al-Chaer E.D. and Willis W.D. Cerebellar activation induced by peripheral injection of capsaicin: a f-MRI / electrophysiology study. International Society for Magnetic Resonance in Medicine (ISMRM), Pennsylvania, May, 1999.
37. Kawasaki M., Pasricha, P.J. and Al-Chaer, E.D. Blockade of NK1 receptors in the spinal cord reduces the hypersensitivity associated with colorectal distension in an animal model of the irritable bowel syndrome. Gastroenterology 118 (4) #4418, 2000.
38. Broussard, R.F., Kawasaki M. and Al-Chaer, E.D. The dorsal column of the spinal cord facilitates spinal neuronal sensitization associated with colorectal hypersensitivity in an animal model of the irritable bowel sydrome. Gastroenterology 118 (4) #5355, 2000.
39. Pasricha, P.J., Kawasaki M. and Al-Chaer, E.D. Evidence of central neuronal sensitization associated with colorectal hypersensitivity in an animal model of the irritable bowel sydrome. Gastroenterology 118 (4) #5480, 2000.
40. Al-Chaer, E.D., Pasricha, P.J. and Kawasaki M. Evidence of central neuronal sensitization associated with chronic visceral hypersensitivity residual to neonatal colon irritation in rats. Federation of European Neuroscience Societies, 2000.
41. Saab, C.Y., Kawasaki M., Masaad, C.A., Saadé, N.E., Al-Chaer, E.D. and Willis W.D. Is the cerebellum involved in analgesia or Pain? Society for Neuroscience, 2000.
42. Saab C.Y., Kawasaki M, Al-Chaer E.D. and Willis W.D. Cerebellar modulation of spinal nociceptive responses: Can pain be influenced from the cerebellum? American Pain society, 19th Annual Scientific Meeting, Atlanta, Georgia, November 2-5, 2000.
43. Al-Chaer, E.D., M. Kawasaki and R.F. Broussard. Does the dorsal column control access of visceral information to other sensory channels in the spinal cord? Society for Neuroscience, 2000.
44. Kawasaki M., Ushida, T. and Al-Chaer, E.D. Intradermal capsaicin attenuates responses of spinal cord neurons to colorectal distension: characteristics of viscerosomatic convergence or DNICs? Society for Neuroscience, 2000.
45. Al-Chaer, E.D. and M. Kawasaki. Rekindling of neuronal sensitization in the spinal cord by the dorsal column in an animal model of chronic visceral pain. American Pain Society, 2000.
46. Al-Chaer, E.D. and Y. Park. Sensitization of electromyographic responses in an animal model of chronic visceral hypersensitivity. Society for Neuroscience, 2001.
47. Park, Y. and Al-Chaer, E.D. Thoracolumbar neuronal sensitization in an animal model of chronic visceral hypersensitivity. Society for Neuroscience, 2001.
48. Park, Y. and Al-Chaer, E.D. Thalamic stimulation differentially modifies spinal neuronal responses to colorectal distension in rats with chronic visceral pain. The Journal of Pain 3(2) Supp.1: page 31, #722. American Pain Society, 2002.
49. Lin, C. and Al-Chaer, E.D. Primary afferent sensitization in an animal model of chronic visceral pain. The Journal of Pain 3(2) Supp.1: page 27, #706. American Pain Society, 2002. 50. Ma, H., Park, Y. and Al-Chaer, E.D. Functional outcomes of neonatal colon pain measured in adult rats. The Journal of Pain 3(2) Supp.1: page 27, #707. American Pain Society, 2002.
51. Park, Y. and Al-Chaer, E.D. Thoracolumbar neuronal sensitization to colon stimuli in Al-Chaer's animal model of chronic visceral pain. The Journal of Pain 3(2) Supp.1: page 27, #708. American Pain Society, 2002.
52. Lin, C. and Al-Chaer, E.D. Exploratory activity in female rats with neonatal colon irritation varies with the estrus cycle. International Association for the Study of Pain (IASP): August 2002, San Diego, CA.
53. Lin, C. and Al-Chaer, E.D. Sensitization of thoracolumbar primary afferent responses to colorectal distension (CRD) in an animal model of chronic visceral pain. Program No. 451.10. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.
54. Hinze, C.L., Lin C. and Al-Chaer, E.D. Estrous cycle and stress related variations of open field activity in adult female rats with neonatal colon irritation (CI). Program No. 155.14. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.
55. Al-Chaer, E.D. and Lin, C. Sex-related differences in exploratory activity in adult rats exposed to neonatal colon pain. Program No. 482.8. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. CD-ROM.
56. Lin, C. and Al-Chaer, E.D. Differential effects of NMDA and non-NMDA receptor antagonists on visceroceptive dorsal horn neurons in adult rats exposed to neonatal colon pain. Program No. 482.9. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. CD-ROM.
57. Al-Chaer, E.D. and Park, Y-C. Sensitization of spinal thoracolumbar neurons to colon stimuli in adult rats exposed to neonatal colon pain. DDW, W1429, Gastroenterology 2003.
58. Wang, J., Peng, Xin and Al-Chaer, E.D. Sex-related differences in visceral sensitivity in adult rats with neonatal colon pain. Gastroenterology 126 (4) (Suppl. 2): A-161 (S1090), 2004.
59. Wang, J., Xie J. and Al-Chaer, E.D. Plastic changes in the role of N-methyl-D-aspartate (NMDA) receptors in the behavioral responses to colorectal distension (CRD) in adult rats exposed to neonatal colon irritation (CI). Gastroenterology 126 (4) (Suppl. 2): A-161 (S1091), 2004.
60. Xie, J., Song, R.H., Wang, J., and Al-Chaer, E.D. Up-regulation of NR1 subunit of N-methyl-D-aspartate (NMDA) receptors in adult rats with neonatal colon irritation and behavioral implications. Gastroenterology 126 (4) (Suppl. 2): A-161 (S1103), 2004.
61. J. Wang,
E.D. Al-Chaer.
Role of N-methyl-D-aspartate (NMDA) receptors in sensitization
of A
62. J. Xie, J. Wang, E.D. Al-Chaer. Role of N-methyl-D-aspartate (NMDA) receptors in the visceral hypersensitivity of adult rats exposed to neonatal colon irritation (CI). Program No. 172.11. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.
63. R.H. Song, J. Xie, J. Wang, E.D. Al-Chaer. Differential regulation of NR1 subunit of N-methyl-D-aspartate (NMDA) receptor in the spinal cord (SC) and dorsal root ganglia (DRG) of adult rats exposed to neonatal colon pain and behavioral implications. Program No. 172.12. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.
64. X. Peng, J. Wang, E.D. Al-Chaer. Sex-related differences in visceral sensitivity in adult rats with neonatal colon pain Program No. 172.13. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. 65. Jing Wang, Chunping Gu, Xin Peng, Kirsten Garner and Elie D. Al-Chaer. Estrogen modulates visceral sensitivity in rats. Program No. 52.7, 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005.
66. Chunping Gu, Jing Wang, Xin Peng, Kirsten Garner, Cheng Wang and Elie D. Al-Chaer. Nenonatal colon irritation induces alterations in mRNA and protein expression of NMDA receptor NR1 subunit in rats. Program No. 52.8, 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005.
67. Jing Wang, Chunping Gu, Xin Peng, Kirsten Garner and Elie D. Al-Chaer. Estrogen modulates visceral sensitivity in adult rats exposed to neonatal colon irritation (CI). DDW 2006. Gastroenterology 130 (4) S2: S1749, p. A-249, 2006.
68. Jing Wang, Kirsten Garner and Elie D. Al-Chaer. Gonadal hormones modulate stress-induced visceral hypersensitivity in rats. DDW 2006. Gastroenterology 130 (4) S2: S1773, p. A-254, 2006.
69. C. Gu, J. Wang, E. D. Al-Chaer. Neonatal intracolonic zymosan: a new model of post-inflammatory chronic visceral hypersensitivity in adult rats. Program No. 142.14. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006.
70. J. Wang, C. Gu, C. Y. Saab, E. D. Al-Chaer. Glial cells: a newly-discovered role in visceral hypersensitivity? Program No. 142.15. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006.
71. Jing Wang, Kirsten Garner, Chunping Gu, Carl Y. Saab, and E. D. Al-Chaer. Glial cells: a newly-discovered role in visceral hypersensitivity? DDW 2007, Gastroenterology 132 (4) S2: T2001, p. A-600, 2007.
72. E. D. Al-Chaer, C. Gu, A. Hayar. An improved method for patch clamp recording of neurons in the intact dorsal root ganglion (DRG) in rats. Program No. 725.16. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007.
73. J. Wang, E.D. Al-Chaer. Sex hormones modulate primary afferent responses to colorectal distension (CRD) in rats. Program No. 725.15. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007.
74. Al-Chaer E.D., Gu C., Soni P., Garner K.N., Fann A., Wang J. Neonatal Cuddling Prevents the Development of Adverse Consequences of Neonatal Injury in Rats. Pediatric Academic Societies Meeting, Honolulu, Hawaii, #4454.14, 2008.
75. Archana Rao, Elie D. Al-Chaer, and Beverley Greenwood-Van Meerveld. Repetitive Colorectal Distension in Neonatal Rats Induces Colonic Mucosal and Muscular Dysfunction in Adulthood. Abstract #807, Digestive Disease Week, San Diego 2008
76. Jing Wang, Chunping Gu, and Elie D. Al-Chaer. Sex Differences in the Characteristics and Role of the Postsynaptic Dorsal Column (PSDC) Pathway in Visceral Pain. Abstract #T1434, Digestive Disease Week, San Diego 2008.
77. Al-Chaer E.D., Gu C. and Wang J. Sex Differences in the Characteristics and Role of Visceral Pain Pathways. Presentation Number: PM 312, 12th World Congress on Pain, Glasgow, UK, 2008.
Manuscripts in preparation:
Book Chapters:
1. Elie D. Al-Chaer and Shelley A. Weaver. Early life trauma and chronic pain. In “Functional Pain Syndromes: Presentation and Pathophysiology”, Emeran Mayer and Catherine Bushnell, Editors.
Original Scientific Articles:
1. Wang, J., Peng, X., and Al-Chaer, E.D. Role of N-methyl-D-aspartate (NMDA) receptors in the visceral hypersensitivity to colorectal distension (CRD) in adult rats exposed to neonatal colon irritation (CI).
2. Al-Chaer, E.D., Quast M., Feng, Y., Wei, J., Gondesen, K. Illangasekare, N., and Willis, W.D. Brain imaging during noxious visceral stimulation: long term effect of a limited midline myelotomy.
3. Chen, P.S., Houghton, A.K., Rees, H., Al-Chaer, E.D., Tsuruoka, M., Westlund, K.N. and Willis, W.D. Evidence of anterior pretectal nucleus evoked inhibition of primate spinothalamic cells using both electrical and chemical stimulation.
4. Al-Chaer, E.D. and Willis, W.D. Visceral information flow into the nucleus tractus solitarius: spinal and extraspinal pathways.
5. Rees, H., Al-Chaer, E.D., Tsuruoka, M. Chen, P.-S., Houghton, A.K., Westlund, K.N. and Willis, W.D. Effect of spinal adrenergic antagonists on anterior pretectal inhibition in the anaesthetized primate.
6. Al-Chaer, E.D., Saadé,N.E., Atweh, S.F. and Jabbur, S.J. Dorsal column input into the nucleus locus ceoruleus in cat.
7. Al-Chaer, E.D., Saadé,N.E., Atweh, S.F. and Jabbur, S.J. Modulation of discharges of cuneate neurons (CN) by conditioning stimuli to the lateral and medial vestibular nuclei.
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afferent fibers to colorectal distension (CRD) in adult rats
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